Activating Macrophages

Over-expressing CD47 is one of the many mechanisms utilized by tumor cells to evade macrophage surveillance. To recapture the evasion, we have engineered a recombinant SIRPα-Fc fusion protein that can block the interaction between macrophage SIRPα receptor and its ligand CD47 on tumor cells. Meanwhile, the Fc portion of our SIRPα-Fc fusion protein can bind Fcγ receptors (FcγRI, FcγRIIa, FcγRIIIa) and activate phagocytosis.